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3-Hydroxyphencyclidine (commonly known as 3-HO-PCP) is a novel dissociative substance of the arylcyclohexylamine class that produces potent dissociative, hallucinogenic, and euphoric effects when administered.


In addition to its primary activity as an NMDA receptor antagonist, it has been found to have an appreciable affinity for the μ-opioid receptor.


It was first synthesised in 1978 to investigate the structure-activity relationship of phencyclidine (PCP) derivatives.


It was further explored alongside PCP in the 1980s, where it was discovered to possess μ-opioid agonist activity in animal models.


Chemistry & Background Information


The structure of 3-Hydroxyphencyclidine consists of cyclohexane. It’s a six-membered saturated ring.

It consists of a piperidine ring and an aromatic phenyl ring.


It was further explored together with phencyclidine in the 1980s. Researchers discovered that it possesses μ-opioid agonists.


Like other substances in the arylcyclohexylamine class, particularly methoxetamine, phencyclidine, and 3-MeO-PCE, 3-HO-PCP is referred to as “dissociative anaesthesia”, albeit the extent to which this occurs has been reported to be highly dose-dependent and variable in its research outcomes.


Chemical Formula:


Product Name: 3-HO-PCP

Other Name(s): 3-Hydroxyphencyclidine; PCP-3-OH

IUPAC Name: 1-[1-(3-hydroxyphenyl)cyclohexyl]-piperidine hydrochloride

CAS: 79787-43-2

Molar Mass: 295.9 g/mol

Purity: 99,8% and above


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