Alpha PHP (a-PHP)
Alpha-PHP (α-Pyrrolidinohexanophenone) is a synthetic stimulant belonging to the cathinone class and part of the pyrrolidinophenone subgroup. It is chemically related to alpha-PVP but distinguished by a longer alkyl side chain, specifically a hexanone backbone. Alpha-PHP is typically available as a crystalline solid or powder used primarily in research settings to investigate stimulant pharmacology and novel psychoactive compound effects.
Chemical Properties and Specifications
2.1 Structural and Molecular Characteristics
Chemical Formula: C16H23NO
Molecular Weight: 245.36 g/mol
CAS Number: 13415-59-3 (hydrochloride salt)
IUPAC Name: 1-Phenyl-2-(pyrrolidin-1-yl)hexan-1-one
Synonyms:
α-PHP
Alpha-Pyrrolidinohexanophenone
Alpha-PHP hydrochloride (salt form)
2.2 Physical Properties and Purity Standards
Appearance: Transparent to whitish crystals or beige to brownish granular powder
Purity: Typically ≥98% for research-grade material
Solubility: Water solubility at 25°C approximately 39.8 mg/L; soluble in organic solvents such as DMSO, DMF, ethanol
Storage Recommendations: Store in a tightly sealed container, away from moisture and light, ideally at -20°C for long-term stability
Pharmacological Profile and Mechanism of Action
3.1 Proposed Mechanism of Action
Alpha-PHP acts as a potent central nervous system stimulant by inhibiting the reuptake and promoting the release of dopamine, norepinephrine, and to a lesser extent serotonin in synapses. It functions primarily as a monoamine transporter substrate and reuptake inhibitor. Its action results in increased extracellular neurotransmitter levels, leading to heightened alertness, energy, and euphoria consistent with synthetic cathinone effects.
3.2 Research Applications
Alpha-PHP is used as a model chemical in studies related to psychoactive stimulant mechanisms, neurotransmitter transport modulation, and the pharmacokinetics of synthetic cathinones. It is also employed in forensic toxicology to develop detection and identification techniques for new psychoactive substances appearing in illicit drug markets.
Comparative Analysis with Related Compounds
4.1 Compare the compound to Compound(s) often compared to
Alpha-PHP is structurally similar to alpha-PVP but differs by an extended alkyl chain, which influences potency, duration, and pharmacokinetics. When compared to other pyrovalerone derivatives like MDPV or α-PBP, alpha-PHP typically exhibits a longer duration and increased potency. Its stimulant profile is comparable to these compounds but is distinct in metabolism and receptor interaction.
4.2 Advantages for Research
Its well-defined chemical properties and characterized behavior make alpha-PHP valuable for systematic studies into cathinone-type stimulants. Alpha-PHP’s distinct alkyl chain length provides insights into structure-activity relationships within the pyrrolidinophenone subclass. High purity ensures reproducible assay results in both in vitro and in vivo contexts.
Safety and Handling Guidelines
5.1 Laboratory Safety
Handle alpha-PHP with appropriate personal protective equipment, including gloves, lab coat, and eye protection. Conduct procedures in a ventilated environment or fume hood. Avoid inhalation, ingestion, and skin contact with powders or solutions.
5.2 Disposal and Environmental Considerations
Dispose of alpha-PHP waste according to local chemical hazardous waste regulations. Avoid release to the environment and use designated containers for discarded materials.
5.3 Regulatory Status
Alpha-PHP is controlled or prohibited in many countries under synthetic cathinone regulations or analogue laws. It is classified as a Schedule I substance in the US and regulated across Europe. Users must comply with all applicable legal provisions before possessing or researching this compound.
Frequently Asked Questions (FAQs)
What is the molecular formula of alpha-PHP?
The formula is C16H23NO.
How soluble is alpha-PHP in water?
Approximately 39.8 mg/L at 25°C.
What is the mechanism of alpha-PHP’s stimulant effect?
It inhibits dopamine and norepinephrine reuptake and promotes their release.
How is alpha-PHP different from alpha-PVP?
Alpha-PHP has a longer alkyl chain, affecting potency and duration.
Is alpha-PHP a controlled substance?
Yes, it is regulated or banned in many jurisdictions.
Conclusion
Alpha-PHP is a potent synthetic cathinone stimulant distinguished by its hexanophenone structure, widely studied for monoaminergic stimulation and forensic detection. Its defined chemical properties, high purity, and specific pharmacological profile make it an important research chemical, requiring thorough safety and regulatory compliance.
Not For Human Consumption” and age-gating at 21+
All products sold by Pure Tech Chemicals are intended for laboratory and research purposes only. They are not for human consumption, veterinary use, or medical applications. You must be 21 years or older to purchase. Misuse of these products is
